{"id":37,"date":"2016-11-27T10:30:17","date_gmt":"2016-11-27T10:30:17","guid":{"rendered":"http:\/\/www.cardiomath.net\/?page_id=37"},"modified":"2018-05-20T11:12:50","modified_gmt":"2018-05-20T10:12:50","slug":"cardiovascular-disease","status":"publish","type":"page","link":"http:\/\/www.cardiomaths.net\/index.php\/research\/cardiovascular-disease\/","title":{"rendered":"Cardiovascular Disease"},"content":{"rendered":"

The body’s ability to form blood clots is its natural defence against bleeding but blood clots formed inappropriately (thrombus) can block blood flow and therefore lead to heart attacks and strokes. A clot is principally formed from two components, small anuclear cells (platelets) and fibrin monomers.<\/p>\n

Platelet Activation<\/h3>\n

In the ICMR at the University of Reading we are producing mathematical models of platelet activation – The VirtualPlatelet. An online app that allows you to run simulations of the above models is available here<\/a>.\u00a0 This work is funded by \u00a0 \"bhflogored\"<\/p>\n

Dunster et al. (2015). Regulation of early steps of GPVI signal transduction by phosphatases: a systems biology approach. PLoS Comput Biol<\/i>, 11<\/i>(11), p.e1004589<\/a>.<\/div>\n
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Mazet et al. (2015). A high-density immunoblotting methodology for quantification of total protein levels and phosphorylation modifications. Scientific reports<\/i>, 5<\/i><\/a><\/div>\n
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Coagulation Cascade<\/h3>\n
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In collaboration with researchers from the Department of Cardiovascular Sciences at the University of Leicester, the\u00a0Leicester Cardiovascular Biomedical Research Unit<\/a> and Moscow State University we are analysing and utilising mathematical models of the coagulation cascade (that leads to the formation of fibrin monomers).<\/p>\n<\/div>\n

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Dunster, J.L. and King, J.R., (2016). Mathematical modelling of thrombin generation: asymptotic analysis and pathway characterization. IMA Journal of Applied Mathematics<\/i>, p.hxw007.<\/a><\/div>\n
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A.V. Belyaev et al. (2018). Modelling thrombosis in silico: frontiers, challenges, unresolved problems and milestones. Physics of life reviews<\/i>, p.hxw007.<\/a><\/div>\n
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The body’s ability to form blood clots is its natural defence against bleeding but blood clots formed inappropriately (thrombus) can block blood flow and therefore lead to heart attacks and strokes. A clot is principally formed from two components, small anuclear cells (platelets) and fibrin monomers. Platelet Activation In the ICMR at the University of […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":13,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/full-width.php","meta":[],"_links":{"self":[{"href":"http:\/\/www.cardiomaths.net\/index.php\/wp-json\/wp\/v2\/pages\/37"}],"collection":[{"href":"http:\/\/www.cardiomaths.net\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.cardiomaths.net\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.cardiomaths.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.cardiomaths.net\/index.php\/wp-json\/wp\/v2\/comments?post=37"}],"version-history":[{"count":22,"href":"http:\/\/www.cardiomaths.net\/index.php\/wp-json\/wp\/v2\/pages\/37\/revisions"}],"predecessor-version":[{"id":174,"href":"http:\/\/www.cardiomaths.net\/index.php\/wp-json\/wp\/v2\/pages\/37\/revisions\/174"}],"up":[{"embeddable":true,"href":"http:\/\/www.cardiomaths.net\/index.php\/wp-json\/wp\/v2\/pages\/13"}],"wp:attachment":[{"href":"http:\/\/www.cardiomaths.net\/index.php\/wp-json\/wp\/v2\/media?parent=37"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}